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Biophysical Journal 63: 569-572 (1992)
© 1992 the Biophysical Society

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23Na and 1H NMR studies on melittin channels activated by tricyclic tranquilizers.

H Tanaka, K Matsunaga and H Kawazura

Faculty of Pharmaceutical Sciences, Josai University, Saitama, Japan.

ABSTRACT

A dynamic 23Na nuclear magnetic resonance (NMR) technique was applied to the exchange system of Na+ ions present inside and outside large unilamellar vesicles at an equivalent concentration. Addition of melittin to phosphatidylcholine vesicles did not induce any detectable Na+ transport across the membrane but subsequent addition of a trace of chlorpromazine or imipramine did induce Na+ transport. Because the formation of a drug-melittin adduct in a solution was detected by 1H NMR, the activation of melittin channels was assumed to originate from the direct interaction of the drug and melittin.






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Copyright © 1992 by the Biophysical Society.