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Biophysical Journal 63: 926-934 (1992)
© 1992 the Biophysical Society

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Effect of firing rate on the calcium permeability in adult neurons during spontaneous action potentials.

M Mazzanti, A Galli and A Ferroni

Dipartimento di Fisiologia e Biochimica Generali, Universitá Statale di Milano, Italy.

ABSTRACT

Calcium channels in neurons mediate a wide variety of essential functions. In addition to contributing to action potential shape, they furnish a substrate that acts as an intracellular second messenger. This study shows that the shape of the neuronal action potential has characteristics that promote long openings of L-type (high threshold) calcium channels. We also present evidence that a change in the firing rate of isolated neurons modulates gating of single calcium channels. This mechanism could be important in modulating neuron excitability and providing a rise in intracellular Ca, when needed.






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Copyright © 1992 by the Biophysical Society.