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Biophysical Journal 64: 68-76 (1993)
© 1993 the Biophysical Society

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Fluctuations in ion channel gating currents. Analysis of nonstationary shot noise.

S C Crouzy and F J Sigworth

Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06510.

ABSTRACT

Conti and Stühmer (1989. Eur. Biophys. J. 17:53-59) have measured the nonstationary shot noise in the gating current of a population of sodium channels. Here we present expressions for the autocovariance and variance of such noise from general Markov models of channel kinetics, based on the theoretical work of E. Frehland. We compare the predictions of the independent, two-state gating model used by Conti and Stühmer with a six-state model of sodium channel activation based on the work of Armstrong and Gilly (1979. J. Gen. Physiol. 74:691-711). We find that Conti and Stühmer's experiment would not be able to distinguish between these schemes. We describe experimental conditions under which better model discrimination would be possible.






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Copyright © 1993 by the Biophysical Society.