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Biophysical Journal 64: 1210-1214 (1993)
© 1993 the Biophysical Society

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Structural transformation of collagen fibrils in corneal stroma during drying. An x-ray scattering study.

P Fratzl and A Daxer

Institut für Festkörperphysik der Universität Wien, Vienna, Austria.

ABSTRACT

X-ray scattering experiments were performed on human corneas during drying. In a first stage the collagen interfibrillar distance decreased considerably. Then, at a critical point of dehydration, a structural transformation of the collagen fibrils was observed. This finding leads to a two-stage drying model, which explains the discrepancy between the collagen fibril diameters determined by x-ray scattering and by electron microscopy. Our results strongly suggest that the collagen fibrils in the corneal stroma are surrounded by a cylindrical coating made mainly of proteoglycans. The coating appears as a three-dimensional fractal network with fractal dimension of 2.7 +/- 0.1.




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Copyright © 1993 by the Biophysical Society.