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Biophysical Journal 64: 1394-1397 (1993)
© 1993 the Biophysical Society

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Salt dependent premelting base pair opening probabilities of B and Z DNA Poly [d(G-C)] and significance for the B-Z transition

Y. Z. Chen and E. W. Prohofsky

Department of Physics, Purdue University West Lafayette, Indiana 47907-1396 USA

ABSTRACT

We calculate room temperature thermal fluctuational base pair opening probabilities of B and Z DNA Poly[d(G-C)] at various salt concentrations and discuss the significance of thermal fluctuation in facilitating base pair disruption during B to Z transition. Our calculated base pair opening probability of the B DNA at lower salt concentrations and the probability of the Z DNA at high salt concentrations are in agreement with observations. The salt dependence of the probabilities indicates a B to Z transition at a salt concentration close to the observed concentration.






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Copyright © 1993 by the Biophysical Society.