Biophysical Journal 67: 1252-1259 (1994)
© 1994 the Biophysical Society

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An estimated shape function for drift in a platelet-transport model.

Department of Biomedical Engineering, University of Miami, Coral Gables, Florida 33124.

ABSTRACT

Prior work has shown that concentration profiles of platelets in flowing whole blood and of platelet-sized beads in flowing blood suspensions can include near-wall excesses. A model to describe this phenomenon was built about a single-component convective diffusion equation. To incorporate redistribution to preferred sites by shear flows of red cell suspensions, the model used a drift shape function (in addition to the commonly used augmented diffusion coefficient). This paper reports experiments that provide an average concentration profile from which the shape function for that model is calculated; the experiments and shape function are for the particular conditions of 40% hematocrit, platelet-sized latex beads (2.5 microns diameter), tube ID of 217 microns, and a wall shear rate of 555 s-1. Less precise estimates of the shape function obtained from data of previous studies indicate that the shape function is similar for the hematocrit of 15%.