| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Biophysical Journal 67: 2272-2279 (1994)
© 1994 the Biophysical Society
Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030.
ABSTRACT
Large conductance calcium-activated K+ (KCa) channels are rapidly activated by niflumic acid dose-dependently and reversibly. External niflumic acid was about 5 times more potent than internal niflumic acid, and its action was characterized by an increase in the channel affinity for [Ca2+], a parallel left shift of the voltage-activation curve, and a decrease of the channel long-closed states. Niflumic acid applied from the external side did not interfere with channel block by charybdotoxin, suggesting that its site of action is not at or near the charybdotoxin receptor. Accordingly, partial tetraethylammonium blockade did not interfere with channel activation by niflumic acid. Flufenamic acid and mefenamic acid also stimulated KCa channel activity and, as niflumic acid, they were more potent from the external than from the internal side. Fenamates applied from the external side displayed the following potency sequence: flufenamic acid approximately niflumic acid >> mefenamic acid. These results indicate that KCa channels possess at least one fenamatereceptor whose occupancy leads to channel opening.
This article has been cited by other articles:
 |
|
 |
|
  D. Fernandez, J. Sargent, F. B. Sachse, and M. C. Sanguinetti Structural Basis for Ether-a-go-go-Related Gene K+ Channel Subtype-Dependent Activation by Niflumic Acid Mol. Pharmacol., April 1, 2008; 73(4): 1159 - 1167. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. K. Fellner and W. J. Arendshorst Angiotensin II-stimulated Ca2+ entry mechanisms in afferent arterioles: role of transient receptor potential canonical channels and reverse Na+/Ca2+ exchange Am J Physiol Renal Physiol, January 1, 2008; 294(1): F212 - F219. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. A. Crowder, M. S. Saha, R. W. Pace, H. Zhang, G. D. Prestwich, and C. A. Del Negro Phosphatidylinositol 4,5-bisphosphate regulates inspiratory burst activity in the neonatal mouse preBotzinger complex J. Physiol., August 1, 2007; 582(3): 1047 - 1058. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Pace, D. D. Mackay, J. L. Feldman, and C. A. Del Negro Inspiratory bursts in the preBotzinger complex depend on a calcium-activated non-specific cation current linked to glutamate receptors in neonatal mice J. Physiol., July 1, 2007; 582(1): 113 - 125. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. O. Suadicani, C. F. Brosnan, and E. Scemes P2X7 Receptors Mediate ATP Release and Amplification of Astrocytic Intercellular Ca2+ Signaling J. Neurosci., February 1, 2006; 26(5): 1378 - 1385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Peretz, N. Degani, R. Nachman, Y. Uziyel, G. Gibor, D. Shabat, and B. Attali Meclofenamic Acid and Diclofenac, Novel Templates of KCNQ2/Q3 Potassium Channel Openers, Depress Cortical Neuron Activity and Exhibit Anticonvulsant Properties Mol. Pharmacol., April 1, 2005; 67(4): 1053 - 1066. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Ledoux, I. A. Greenwood, and N. Leblanc Dynamics of Ca2+-Dependent Cl- Channel Modulation by Niflumic Acid in Rabbit Coronary Arterial Myocytes Mol. Pharmacol., January 1, 2005; 67(1): 163 - 173. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Schiller Activation of a Calcium-Activated Cation Current During Epileptiform Discharges and Its Possible Role in Sustaining Seizure-Like Events in Neocortical Slices J Neurophysiol, August 1, 2004; 92(2): 862 - 872. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. M. Pocock, R. R. Foster, and D. O. Bates Evidence of a role for TRPC channels in VEGF-mediated increased vascular permeability in vivo Am J Physiol Heart Circ Physiol, March 1, 2004; 286(3): H1015 - H1026. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Bertrand, H. Danahay, C. T. Poll, C. Laboisse, U. Hopfer, and R. J. Bridges Niflumic acid inhibits ATP-stimulated exocytosis in a mucin-secreting epithelial cell line Am J Physiol Cell Physiol, February 1, 2004; 286(2): C247 - C255. [Abstract] [Full Text]
|
|
|
|
|
|
M. Srinivas and D. C. Spray Closure of Gap Junction Channels by Arylaminobenzoates Mol. Pharmacol., June 1, 2003; 63(6): 1389 - 1397. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. G. A. Harks, A. D. G. de Roos, P. H. J. Peters, L. H. de Haan, A. Brouwer, D. L. Ypey, E. J. J. van Zoelen, and A. P. R. Theuvenet Fenamates: A Novel Class of Reversible Gap Junction Blockers J. Pharmacol. Exp. Ther., September 1, 2001; 298(3): 1033 - 1041. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. E. Daniel, J. Jury, A. M. Salapatek, T. Bowes, A. Lam, S. Thomas, M. Ramnarain, V. Nguyen, and V. Mistry Nitric Oxide from Enteric Nerves Acts by a Different Mechanism from Myogenic Nitric Oxide in Canine Lower Esophageal Sphincter J. Pharmacol. Exp. Ther., July 1, 2000; 294(1): 270 - 279. [Abstract] [Full Text]
|
|
|
|
|
|
N. I. Gokina and J. A. Bevan Role of intracellular Ca2+ release in histamine-induced depolarization in rabbit middle cerebral artery Am J Physiol Heart Circ Physiol, June 1, 2000; 278(6): H2105 - H2114. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Yamamura, N. Nagano, M. Hirano, K. Muraki, M. Watanabe, and Y. Imaizumi Activation of Ca2+-Dependent K+ Current by Nordihydroguaiaretic Acid in Porcine Coronary Arterial Smooth Muscle Cells J. Pharmacol. Exp. Ther., October 1, 1999; 291(1): 140 - 146. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. Guia, X. Wan, M. Courtemanche, and N. Leblanc Local Ca2+ Entry Through L-Type Ca2+ Channels Activates Ca2+-Dependent K+ Channels in Rabbit Coronary Myocytes Circ. Res., May 14, 1999; 84(9): 1032 - 1042. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kato, A. M. Evans, and R. Z. Kozlowski Relaxation of Endothelin-1-Induced Pulmonary Arterial Constriction by Niflumic Acid and NPPB: Mechanism(s) Independent of Chloride Channel Block J. Pharmacol. Exp. Ther., March 1, 1999; 288(3): 1242 - 1250. [Abstract] [Full Text]
|
|
|
|
 |
|
 L. J. Janssen, C. Hague, and R. Nana Ionic mechanisms underlying electrical slow waves in canine airway smooth muscle Am J Physiol Lung Cell Mol Physiol, September 1, 1998; 275(3): L516 - L523. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Salter and R. Z. Kozlowski Differential Electrophysiological Actions of Endothelin-1 on Cl- and K+ Currents in Myocytes Isolated from Aorta, Basilar and Pulmonary Artery J. Pharmacol. Exp. Ther., March 1, 1998; 284(3): 1122 - 1131. [Abstract] [Full Text]
|
|
|
|
 |
|
 G Farrugia, S Nitecki, G J Harty, M Camilleri, and J H Szurszewski The effect of flufenamic acid on gastrointestinal myoelectrical activity and transit time in dogs Gut, February 1, 1998; 42(2): 258 - 265. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-S. Wang, J. E. Dixon, and D. McKinnon Unexpected and Differential Effects of Cl- Channel Blockers on the Kv4.3 and Kv4.2 K+ Channels : Implications for the Study of the Ito2 Current Circ. Res., November 19, 1997; 81(5): 711 - 718. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
