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Biophysical Journal 68: 427-433 (1995)
© 1995 the Biophysical Society

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Extended dipolar chain model for ion channels: electrostriction effects and the translocational energy barrier.

M Sancho, M B Partenskii, V Dorman and P C Jordan

Department of Chemistry, Brandeis University, Waltham, Massachusetts 02254.

ABSTRACT

We reinvestigate the dipolar chain model for an ion channel. Our goal is to account for the influence that ion-induced electrostriction of channel water has on the translocational energy barriers experienced by different ions in the channel. For this purpose, we refine our former model by relaxing the positional constraint on the ion and the water dipoles and by including Lennard-Jones contributions in addition to the electrostatic interactions. The positions of the ion and the waters are established by minimization of the free energy. As before, interaction with the external medium is described via the image forces. Application to alkali cations show that the short range interactions modulate the free energy profiles leading to a selectivity sequence for translocation. We study the influence of some structural parameters on this sequence and compare our theoretical predictions with observed results for gramicidin.




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Copyright © 1995 by the Biophysical Society.