Biophysical Journal 68: 946-948 (1995)
© 1995 the Biophysical Society

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lamb, G D Articles by Stephenson, D G Search for Related Content PubMed PubMed Citation Articles by Lamb, G D Articles by Stephenson, D G

Activation of ryanodine receptors by flash photolysis of caged Ca2+.

School of Zoology, La Trobe University, Bundoora, Melbourne, Victoria, Australia.

ABSTRACT

Flash photolysis of DM-nitrophen generates an extremely large [Ca2+] transient ("Ca2+ spike") at the start of each Ca2+ "step." The Ca2+ spike greatly increases the speed of activation of the ryanodine receptor channel ("supercharging") and could be responsible for apparent channel adaptation.

This article has been cited by other articles:

				R. A. Rosales, M. Fill, and A. L. Escobar Calcium Regulation of Single Ryanodine Receptor Channel Gating Analyzed Using HMM/MCMC Statistical Methods J. Gen. Physiol., April 26, 2004; 123(5): 533 - 553. [Abstract] [Full Text] [PDF]

				A. Zahradnikova, M. Dura, I. Gyorke, A. L. Escobar, I. Zahradnik, and S. Gyorke Regulation of dynamic behavior of cardiac ryanodine receptor by Mg2+ under simulated physiological conditions Am J Physiol Cell Physiol, November 1, 2003; 285(5): C1059 - C1070. [Abstract] [Full Text] [PDF]

				S. Giovannardi, L. Lando, and A. Peres Flash Photolysis of Caged Compounds: Casting Light on Physiological Processes Physiology, October 1, 1998; 13(5): 251 - 255. [Abstract] [Full Text] [PDF]

				R. Sitsapesan, R. A.P. Montgomery, and A. J. Williams New Insights Into the Gating Mechanisms of Cardiac Ryanodine Receptors Revealed by Rapid Changes in Ligand Concentration Circ. Res., October 1, 1995; 77(4): 765 - 772. [Abstract] [Full Text]