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Biophysical Journal 68: 323s (1995)
© 1995 the Biophysical Society

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Activation of Dynein-Mediated in Vitro Microtubule Translocation via Phosphorylation of a 29kDa Light Chain

Toshikazu Hamasaki, Inpakala Simon, Kurt Barkalow and Peter Satir

Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461 USA

ABSTRACT

To explain how a substoichiometric amount of phosphorylation of a 29-kDa dynein light chain (p29) activates microtubule translocation in vitro, we constructed a "pacemaker" hypothesis. An example of a translocating microtubule that follows the hypothesis is demonstrated.






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Copyright © 1995 by the Biophysical Society.