| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Biophysical Journal 68: 2323-2332 (1995)
© 1995 the Biophysical Society
Mathematical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
ABSTRACT
S. Bordin and colleagues have proposed that the depolarizing effects of acetylcholine and other muscarinic agonists on pancreatic beta-cells are mediated by a calcium release-activated current (CRAC). We support this hypothesis with additional data, and present a theoretical model which accounts for most known data on muscarinic effects. Additional phenomena, such as the biphasic responses of beta-cells to changes in glucose concentration and the depolarizing effects of the sarco-endoplasmic reticulum calcium ATPase pump poison thapsigargin, are also accounted for by our model. The ability of this single hypothesis, that CRAC is present in beta-cells, to explain so many phenomena motivates a more complete characterization of this current.
Related articles in Biophys. J.:
This article has been cited by other articles:
 |
|
 |
|
  J. Herrington, M. Sanchez, D. Wunderler, L. Yan, R. M Bugianesi, I. E Dick, S. A Clark, R. M Brochu, B. T Priest, M. G Kohler, et al. Biophysical and pharmacological properties of the voltage-gated potassium current of human pancreatic {beta}-cells J. Physiol., August 15, 2005; 567(1): 159 - 175. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Bertram and A. Sherman Filtering of Calcium Transients by the Endoplasmic Reticulum in Pancreatic {beta}-Cells Biophys. J., December 1, 2004; 87(6): 3775 - 3785. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Soria, I. Quesada, A. B. Ropero, J. A. Pertusa, F. Martin, and A. Nadal Novel Players in Pancreatic Islet Signaling: From Membrane Receptors to Nuclear Channels Diabetes, February 1, 2004; 53(90001): S86 - 91. [Abstract] [Full Text]
|
|
|
|
|
|
M. J. Riedel, P. Boora, D. Steckley, G. de Vries, and P. E. Light Kir6.2 Polymorphisms Sensitize {beta}-Cell ATP-Sensitive Potassium Channels to Activation by Acyl CoAs: A Possible Cellular Mechanism for Increased Susceptibility to Type 2 Diabetes? Diabetes, October 1, 2003; 52(10): 2630 - 2635. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Zhang, P. Goforth, R. Bertram, A. Sherman, and L. Satin The Ca2+ Dynamics of Isolated Mouse {beta}-Cells and Islets: Implications for Mathematical Models Biophys. J., May 1, 2003; 84(5): 2852 - 2870. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Qian, P. Huang, L. Ma, A. Kuznetsov, N. Tamarina, and L. H. Philipson TRP Genes: Candidates for Nonselective Cation Channels and Store-Operated Channels in Insulin-Secreting Cells Diabetes, February 1, 2002; 51(90001): S183 - 189. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Gilon and J.-C. Henquin Mechanisms and Physiological Significance of the Cholinergic Control of Pancreatic {beta}-Cell Function Endocr. Rev., October 1, 2001; 22(5): 565 - 604. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Dyachok and E. Gylfe Store-operated influx of Ca2+ in pancreatic {beta}-cells exhibits graded dependence on the filling of the endoplasmic reticulum J. Cell Sci., January 6, 2001; 114(11): 2179 - 2186. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. P. LeBeau, F. Van Goor, S. S. Stojilkovic, and A. Sherman Modeling of Membrane Excitability in Gonadotropin-Releasing Hormone-Secreting Hypothalamic Neurons Regulated by Ca2+-Mobilizing and Adenylyl Cyclase-Coupled Receptors J. Neurosci., December 15, 2000; 20(24): 9290 - 9297. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Tengholm, B. Hellman, and E. Gylfe Glucose Regulation of Free Ca2+ in the Endoplasmic Reticulum of Mouse Pancreatic Beta Cells J. Biol. Chem., December 24, 1999; 274(52): 36883 - 36890. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-J. Liu, B. Hellman, and E. Gylfe Ca2+ Signaling in Mouse Pancreatic Polypeptide Cells Endocrinology, December 1, 1999; 140(12): 5524 - 5529. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. J. Butera Jr., J. Rinzel, and J. C. Smith Models of Respiratory Rhythm Generation in the Pre-Botzinger Complex. I. Bursting Pacemaker Neurons J Neurophysiol, July 1, 1999; 82(1): 382 - 397. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Aguilar-Bryan and J. Bryan Molecular Biology of Adenosine Triphosphate-Sensitive Potassium Channels Endocr. Rev., April 1, 1999; 20(2): 101 - 135. [Abstract] [Full Text]
|
|
|
|
 |
|
 S. Dryselius, E. Grapengiesser, B. Hellman, and E. Gylfe Voltage-dependent entry and generation of slow Ca2+ oscillations in glucose-stimulated pancreatic beta -cells Am J Physiol Endocrinol Metab, March 1, 1999; 276(3): E512 - E518. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Magnus and J. Keizer Model of beta -cell mitochondrial calcium handling and electrical activity. I. Cytoplasmic variables Am J Physiol Cell Physiol, April 1, 1998; 274(4): C1158 - C1173. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Hellman, E. Gylfe, P. Bergsten, E. Grapengiesser, A. Berts, Y.-J. Liu, A. Tengholm, and J. Westerlund Oscillatory Signaling and Insulin Release in Human Pancreatic {beta}-Cells Exposed to Strontium Endocrinology, August 1, 1997; 138(8): 3161 - 3165. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Arredouani, J.-C. Henquin, and P. Gilon Contribution of the endoplasmic reticulum to the glucose-induced [Ca2+]c response in mouse pancreatic islets Am J Physiol Endocrinol Metab, May 1, 2002; 282(5): E982 - E991. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
