Biophysical Journal 7: 527-534 (1967)
© 1967 the Biophysical Society

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On the Relative Contribution of Viscous Flow ys. Diffusional (Frictional) Flow to the Stationary-State Flow of Water through a "Tight" Membrane

ABSTRACT

The practice of calculating the diffusion contribution to the total pressure-driven flow of water through a tight membrane by using the self-diffusion coefficient for tritiated water is examined by a theoretical analysis. Equations of motion for water and membrane in pressure-driven water flow and water, membrane, and tritiated water in self-diffusion of tritiated water are adapted from Bearman and Kirkwood (1958). These equations of motion are used to develop an equation for the pressure-driven flow of water. Because of the lack of specific information about the detailed structure of most membranes, as well as considerations of the need to eliminate some of the mathematical difficulties, an "equivalent capillary" model is used to find a solution to the equation of motion. The use of the equivalent capillary model and possible ambiguities in distinctions between diffusion and hydrodynamic flow are discussed