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Biophysical Journal 70: 813-817 (1996)
© 1996 the Biophysical Society

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Gated conductances in native and reconstituted membranes from frog olfactory cilia.

T Nakamura, H H Lee, H Kobayashi and T O Satoh

Department of Applied Physics and Chemistry, University of Electro-Communications, Tokyo, Japan.

ABSTRACT

Although cAMP is well established as a second messenger for olfactory transduction in vertebrates, the role of inositol 1,4,5-trisphosphate (IP3) in this process remains controversial. We addressed this issue by comparing currents evoked by cAMP and IP3 in native and reconstituted membranes from olfactory cilia. We detected only a cyclic nucleotide-gated conductance in the native membrane but both cyclic nucleotide-gated and IP3-gated conductances in the reconstituted membrane. The magnitudes of the cyclic nucleotide- and IP3-gated conductances were not correlated with each other in reconstituted membranes, suggesting that cyclic nucleotide- and IP3-gated channels originate in different cellular compartments.




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Copyright © 1996 by the Biophysical Society.