Biophysical Journal 70: 1198-1213 (1996)
© 1996 the Biophysical Society

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Baran, I Search for Related Content PubMed PubMed Citation Articles by Baran, I

Calcium and cell cycle progression: possible effects of external perturbations on cell proliferation.

Biophysics Laboratory, Biotehnos S.A., Bucharest, Romania. baran@roifa.ifa.ro

ABSTRACT

Exit from the phase of cellular division appears to be driven by a calcium signal that triggers a cascade of events leading to the completion of mitosis. Here we propose a model that relates the dynamics of cytosolic calcium to progression through mitosis, G1 and G2 phases of the cell cycle. To this end, the assumption has been made that the transient rise ir cytosolic calcium concentration during mitosis is induced by inositol(1,4,5)triphosphate (IP3), which in turn is released at high levels of mitosis-promoting factor (MPF). On this basis, a system of ordinary differential equations is proposed to simulate the evolution of ten cell-cycle-specific molecular species, including cyclins A and B, MPF, IP3, Ca2+, the CaMKII holoenzyme, and the ubiquitination complex. The influence on the cell proliferation capacity exerted by external perturbations, like calcium microinjections, depletion of intracellular calcium stores, electromagnetic fields, or stimulation/inhibition of different calcium currents through the plasma membrane, can be studied by appropriate modulation of the parameters involved in the signal transduction pathway.

This article has been cited by other articles:

				I. Baran Integrated Luminal and Cytosolic Aspects of the Calcium Release Control Biophys. J., March 1, 2003; 84(3): 1470 - 1485. [Abstract] [Full Text] [PDF]

				J. Y. Jeremy, D. Rowe, A. M. Emsley, and A. C. Newby Nitric oxide and the proliferation of vascular smooth muscle cells Cardiovasc Res, August 15, 1999; 43(3): 580 - 594. [Full Text] [PDF]

				S. N. MacFarlane and H. Sontheimer Electrophysiological Changes That Accompany Reactive Gliosis In Vitro J. Neurosci., October 1, 1997; 17(19): 7316 - 7329. [Abstract] [Full Text] [PDF]

				N. Ullrich and H. Sontheimer Cell cycle-dependent expression of a glioma-specific chloride current: proposed link to cytoskeletal changes Am J Physiol Cell Physiol, October 1, 1997; 273(4): C1290 - C1297. [Abstract] [Full Text] [PDF]