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Biophysical Journal 71: 86-90 (1996)
© 1996 the Biophysical Society

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Differentiating inclusion complexes from host molecules by tapping-mode atomic force microscopy.

S Muñoz-Botella, M A Martin, B del Castillo and L Vázquez

Sección Departamental de Química Analítica, Facultad de Farmacia, Universidad Complutense de Madrid, Spain.

ABSTRACT

Tapping-mode atomic force microscopy imaging under different cantilever vibration amplitudes has been used to differentiate the host beta-cyclodextrin nanotubes from retinal/beta-cyclodextrin inclusion complex nanotubes. It was observed that both compounds were deformed differently by the applied probe force because of their different local rigidity. This change in the elasticity properties can be explained as a consequence of the inclusion process. This method shows that tapping-mode atomic force microscopy is an useful tool to map soft sample elasticity properties and to distinguish inclusion complexes from their host molecules on the basis of their different mechanical response.






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Copyright © 1996 by the Biophysical Society.