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Biophysical Journal 72: 866-875 (1997)
© 1997 the Biophysical Society

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Quantification of DNA Patchiness Using Long-Range Correlation Measures

G. M. Viswanathan *, S. V. Buldyrev *, S. Havlin * # and H. E. Stanley *

Center for Polymer Studies and Department of Physics, Boston University, Boston, Massachusetts 02215 USA
Gonda-Goldschmied Center and Department of Physics, Bar Ilan University, Ramat Gan, Israel

ABSTRACT

We introduce and develop new techniques to quantify DNA patchiness, and to quantify characteristics of its mosaic structure. These techniques, which involve calculating two functions, {alpha}(l) and ß(l), measure correlations at length scale l and detect distinct characteristic patch sizes embedded in scale-invariant patch size distributions. Using these new methods, we address a number of issues relating to the mosaic structure of genomic DNA. We find several distinct characteristic patch sizes in certain genomic sequences, and compare, contrast, and quantify the correlation properties of different sequences, including a number of yeast, human, and prokaryotic sequences. We exclude the possibility that the correlation properties and the known mosaic structure of DNA can be explained either by simple Markov processes or by tandem repeats of dinucleotides. We find that the distinct patch sizes in all 16 yeast chromosomes are similar. Furthermore, we test the hypothesis that, for yeast, patchiness is caused by the alternation of coding and noncoding regions, and the hypothesis that in human sequences patchiness is related to repetitive sequences. We find that, by themselves, neither the alternation of coding and noncoding regions, nor repetitive sequences, can fully explain the long-range correlation properties of DNA.






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Copyright © 1997 by the Biophysical Society.