help button home button Biophys. J.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

Biophysical Journal 72: 1143-1152 (1997)
© 1997 the Biophysical Society

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Baumgartner, W
Right arrow Articles by Romanin, C
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Baumgartner, W
Right arrow Articles by Romanin, C

Estimating the number of channels in patch-clamp recordings: application to kinetic analysis of multichannel data from voltage-operated channels.

W Baumgartner, K Hohenthanner, G F Höfer, K Groschner and C Romanin

Institute for Biophysics, University of Linz, Austria.

ABSTRACT

Important kinetic information of voltage-operated ion channels can be obtained by estimating the open probability, the availability, and the first latency, and by applying run analysis. In the case of multichannel patches, estimation of the number of available channels is a prerequisite for the above analysis. Here we describe a method for calculation of the a posteriori probability of the number of available channels in each sweep by using the Bayes formula. This probability serves as a measure for the number of channels and allows for first latency determination and run analysis. The methods described were applied to simulated and experimental data obtained from L-type Ca2+ channel recordings.




This article has been cited by other articles:


Home page
 Biophys. JHome page
E. Kobrinsky, K. J. F. Kepplinger, A. Yu, J. B. Harry, H. Kahr, C. Romanin, D. R. Abernethy, and N. M. Soldatov
Voltage-Gated Rearrangements Associated with Differential {beta}-Subunit Modulation of the L-Type Ca2+ Channel Inactivation
Biophys. J., August 1, 2004; 87(2): 844 - 857.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. Wappl, A. Koschak, M. Poteser, M. J. Sinnegger, D. Walter, A. Eberhart, K. Groschner, H. Glossmann, R. L. Kraus, M. Grabner, et al.
Functional Consequences of P/Q-type Ca2+ Channel Cav2.1 Missense Mutations Associated with Episodic Ataxia Type 2 and Progressive Ataxia
J. Biol. Chem., February 22, 2002; 277(9): 6960 - 6966.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
C. A. Obejero-Paz, M. Auslender, and A. Scarpa
PKC activity modulates availability and long openings of L-type Ca2+ channels in A7r5 cells
Am J Physiol Cell Physiol, August 1, 1998; 275(2): C535 - C543.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1997 by the Biophysical Society.