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Biophysical Journal 72: 1582-1594 (1997)
© 1997 the Biophysical Society

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Collective binding properties of receptor arrays.

N Agmon and A L Edelstein

Department of Physical Chemistry, Hebrew University, Jerusalem, Israel. agmon@batata.fh.huji.ac.il

ABSTRACT

Binding kinetics of receptor arrays can differ dramatically from that of the isolated receptor. We simulate synaptic transmission using a microscopically accurate Brownian dynamics routine. We study the factors governing the rise and decay of the activation probability as a function of the number of transmitter molecules released. Using a realistic receptor array geometry, the simulation reproduces the time course of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor-mediated excitatory postsynaptic currents. A consistent interpretation of experimentally observed synaptic currents in terms of rebinding and spatial correlations is discussed.




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Copyright © 1997 by the Biophysical Society.