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Biophysical Journal 72: 1744-1753 (1997)
© 1997 the Biophysical Society

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Single-particle tracking: the distribution of diffusion coefficients.

M J Saxton

Institute of Theoretical Dynamics, University of California, Davis 95616, USA. mjsaxton@ucdavis.edu

ABSTRACT

In single-particle tracking experiments, the diffusion coefficient D may be measured from the trajectory of an individual particle in the cell membrane. The statistical distribution of single-trajectory diffusion coefficients is examined by Monte Carlo calculations. The width of this distribution may be useful as a measure of the heterogeneity of the membrane and as a test of models of hindered diffusion in the membrane. For some models, the distribution of the short-range diffusion coefficient is much narrower than the observed distribution for proteins diffusing in cell membranes. To aid in the analysis of single-particle tracking measurements, the distribution of D is examined for various definitions of D and for various trajectory lengths.




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