Biophysical Journal 73: 1081-1088 (1997)
© 1997 the Biophysical Society

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Helicobacter pylori survival in gastric mucosa by generation of a pH gradient.

Department of Bioengineering, University of Toledo, Ohio 43606, USA.

ABSTRACT

Helicobacter pylori has been established as the major causative agent of human active gastritis and is an essential factor in peptic ulcer disease and gastric cancer. The mechanism that has been proposed for H. pylori to control its inhospitable microenvironment happens to coincide with the pH control technique developed by us. This technique was developed to separate an acidic environment from a basic environment for a sequential enzymatic reaction by the hydrolysis of urea within a thin layer of immobilized urease. In this paper, a mathematical model is presented to consider how H. pylori survives the gastric acidity. The computed results explain well the experimental data available involving H. pylori.

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