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Biophysical Journal 74: 132-137 (1998)
© 1998 the Biophysical Society

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Biophys J, January 1998, p. 132-137, Vol. 74, No. 1

Elasticity Theory of the B-DNA to S-DNA Transition

Amir Ahsan, Joseph Rudnick, and Robijn Bruinsma

Department of Physics, University of California at Los Angeles, Los Angeles, California 90024 USA

We propose in this note a simple model---the two-state Worm Like Chain---to describe the elasticity of the recently discovered stress-induced transformation from B-DNA to S-DNA. The model reduces for low tractions to the well-known Worm Like chain theory, which is used to describe the elastic properties of B-DNA, while in the limit of high chain-bending moduli it reduces to the two-state Ising model proposed by Cluzel et al. for the B-S transition [Cluzel, P., A. Lebrun, C. Heller, R. Lavery, J-L. Viovy, D. Chatenay, and F. Caron. 1996. DNA: an extensible molecule. Science. 271:792-794]. Our model can be treated analytically to produce an explicit form of the force-extension relationship which agrees reasonably with the observations. We use the model to show that conformational fluctuations of the chain play a role also for the B to S transformation.

Biophys J, January 1998, p. 132-137, Vol. 74, No. 1
© 1998 by the Biophysical Society   0006-3495/98/01/132/06  $2.00


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