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Biophysical Journal 74: 175-181 (1998)
© 1998 the Biophysical Society
Biophys J, January 1998, p. 175-181, Vol. 74, No. 1
*Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, United Kingdom, and #Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599-7290 USA
Cells in a cloned population of coliform bacteria exhibit
a wide range of swimming behaviors
a form of non-genetic
individuality. We used computer models to examine the proposition that
these variations are due to differences in the number of chemotaxis signaling molecules from one cell to the next. Simulations were run in
which the concentrations of seven gene products in the chemotaxis
pathway were changed either deterministically or stochastically, with
the changes derived from independent normal distributions. Computer
models with two adaptation mechanisms were compared with experimental
results from observations on individuals drawn from genetically
identical populations. The range of swimming behavior predicted for
cells with a standard deviation of protein copy number per cell of 10%
of the mean was found to match closely the experimental range of the
wild-type population. We also make predictions for the swimming
behaviors of mutant strains lacking the adaptational mechanism that can
be tested experimentally.
Biophys J, January 1998, p. 175-181, Vol. 74, No. 1
© 1998 by the Biophysical Society 0006-3495/98/01/175/07 $2.00
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