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Biophys J, February 1998, p. 1024-1030, Vol. 74, No. 2

Trapping of DNA in Nonuniform Oscillating Electric Fields

Charles L. Asbury and Ger van den Engh

Department of Molecular Biotechnology, University of Washington, Seattle, Washington 98195 USA

DNA molecules can be manipulated in aqueous solution in a manner analogous to optical trapping. Due to the induction of an electric dipole, DNA molecules are pulled by a gradient force to regions of high electric field strength. Molecules can be locally trapped in an oscillating field using strips of very thin gold film to generate strong electric fields with steep gradients. Spatial control over the trapped molecules is achieved because they are confined to a width of ~5 µm along the edges of the gold-film strips. By mixing static and oscillating electric fields, trapped molecules can be moved from one edge to another or made to follow precise trajectories along the edges. This phenomenon should be useful in microdevices for manipulation of small quantities or single molecules of DNA.

Biophys J, February 1998, p. 1024-1030, Vol. 74, No. 2
© 1998 by the Biophysical Society   0006-3495/98/02/1024/07  $2.00


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