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Biophys J, July 1998, p. 174-182, Vol. 75, No. 1

Evidence for a Novel Bursting Mechanism in Rodent Trigeminal Neurons

Christopher A. Del Negro,* Chie-Fang Hsiao,* Scott H. Chandler,* and Alan Garfinkel*#

 *Department of Physiological Science and  #Department of Medicine (Cardiology), University of California at Los Angeles, Los Angeles, California 90095-1568 USA

We investigated bursting behavior in rodent trigeminal neurons. The essential mechanisms operating in the biological systems were determined based on testable predictions of mathematical models. Bursting activity in trigeminal motoneurons is consistent with a traditional mechanism employing a region of negative slope resistance in the steady-state current-voltage relationship (Smith, T. G. 1975. Nature. 253:450-452). However, the bursting dynamics of trigeminal interneurons is inconsistent with the traditional mechanisms, and is far more effectively explained by a new model of bursting that exploits the unique stability properties associated with spike threshold (Baer, S. M., T. Erneux, and J. Rinzel. 1989. SIAM J. Appl. Math. 49:55-71).

Biophys J, July 1998, p. 174-182, Vol. 75, No. 1
© 1998 by the Biophysical Society   0006-3495/98/07/174/09  $2.00


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