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Biophys J, September 1998, p. 1403-1409, Vol. 75, No. 3

The Size of the Unstirred Layer as a Function of the Solute Diffusion Coefficient

Peter Pohl, Sapar M. Saparov, and Yuri N. Antonenko

Medizinische Fakultät, Institut für Medizinische Physik und Biophysik, Martin-Luther-Universität, 06097 Halle, Germany

By monitoring the concentration distribution of several solutes that are diffusing at the same time under given mixing conditions, it was established that the unstirred layer (USL) has no clearly defined boundary. For the cases of solute permeation and water movement across planar bilayer lipid membranes, respectively, experiments carried out with double-barreled microelectrodes have shown that the thickness of the USL depends on which species is diffusing. Small molecules with a larger diffusion coefficient encounter an apparently thicker USL than larger molecules with a smaller diffusion coefficient. The ratio of the USL thicknesses of two different substances is equal to the third root of the ratio of the respective diffusion coefficients. This experimental finding is in good agreement with theoretical predictions from the theory of physicochemical hydrodynamics.

Biophys J, September 1998, p. 1403-1409, Vol. 75, No. 3
© 1998 by the Biophysical Society   0006-3495/98/09/1403/07  $2.00


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