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Biophys J, December 1998, p. 2615-2625, Vol. 75, No. 6

Possible Cooperation of Differential Adhesion and Chemotaxis in Mound Formation of Dictyostelium

Yi Jiang,* Herbert Levine,# and James Glazier*

 *Department of Physics, University of Notre Dame, Notre Dame, Indiana 46556; and  #Department of Physics, University of California at San Diego, La Jolla, California 92093 USA

In the mound stage of Dictyostelium discoideum, pre-stalk cells sort and form a tip at the apex. How this pattern forms is as yet unknown. A cellular level model allows us to simulate both differential cell adhesion and chemotaxis, to show that with differential adhesion only, pre-stalk cells move to the surface of the mound but form no tip. With chemotaxis driven by an outgoing circular wave only, a tip forms but contains both pre-stalk and pre-spore cells. Only for a narrow range of relative strengths between differential adhesion and chemotaxis can both mechanisms work in concert to form a tip containing only pre-stalk cells. The simulations provide a method to determine the processes necessary for patterning and suggest a series of further experiments.

Biophys J, December 1998, p. 2615-2625, Vol. 75, No. 6
© 1998 by the Biophysical Society   0006-3495/98/12/2615/11  $2.00


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