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Biophys J, March 1999, p. 1330-1334, Vol. 76, No. 3

Dynamics of Plaque Formation in Alzheimer's Disease

B. Urbanc,* L. Cruz,* S. V. Buldyrev,* S. Havlin,*# M. C. Irizarry,§ H. E. Stanley,* and B. T. Hyman§

 *Center for Polymer Studies and Department of Physics, Boston University, Boston, Massachusetts 02215 USA;  #Gonda-Goldschmied Center and Department of Physics, Bar-Ilan University, Ramat-Gan, Israel; and  §Neurology Service, Massachusetts General Hospital, Boston, Massachusetts 02114 USA

Plaques that form in the brains of Alzheimer patients are made of deposits of the amyloid-beta peptide. We analyze the time evolution of amyloid-beta deposition in immunostained brain slices from transgenic mice. We find that amyloid-beta deposits appear in clusters whose characteristic size increases from 14 µm in 8-month-old mice to 22 µm in 12-month-old mice. We show that the clustering has implications for the biological growth of amyloid-beta by presenting a growth model that accounts for the experimentally observed structure of individual deposits and predicts the formation of clusters of deposits and their time evolution.

Biophys J, March 1999, p. 1330-1334, Vol. 76, No. 3
© 1999 by the Biophysical Society   0006-3495/99/03/1330/05  $2.00


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R. H. Christie, B. J. Bacskai, W. R. Zipfel, R. M. Williams, S. T. Kajdasz, W. W. Webb, and B. T. Hyman
Growth Arrest of Individual Senile Plaques in a Model of Alzheimer's Disease Observed by In Vivo Multiphoton Microscopy
J. Neurosci., February 1, 2001; 21(3): 858 - 864.
[Abstract] [Full Text] [PDF]


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