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Biophys J, May 1999, p. 2520-2529, Vol. 76, No. 5

A Three-State Model for Connexin37 Gating Kinetics

S. V. Ramanan,* P. R. Brink,* K. Varadaraj,* E. Peterson,* K. Schirrmacher,# and K. Banach*

 *Department of Physiology and Biophysics, State University of New York at Stony Brook, Stony Brook, New York 11794-8661 USA, and  #Institut für Physiologie, Universität-GH Essen, D-45122 Essen, Germany

The gating behavior of human connexin 37 (hCx37) is unaffected by the nature of the bathing monovalent (for Na, K, Rb). It is modified by [Mg] in the millimolar range. For fitting the kinetics, we propose a simple extension to three states of the canonical 2-state model of the hemichannel. The extra closed state allows for some immobilization of a hemichannel at high transjunctional voltages. The model is reasonably efficient at fitting data at various voltage protocols. Interpreting the fits of the data at different [Mg] is consistent with a binding site for Mg.

Biophys J, May 1999, p. 2520-2529, Vol. 76, No. 5
© 1999 by the Biophysical Society   0006-3495/99/05/2520/10  $2.00


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