| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Biophys J, October 1999, p. 1936-1944, Vol. 77, No. 4
*Department of Molecular Physiology and Biophysics and #Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030 USA; §Image Science Software GmbH, D-10711 Berlin, Germany; and ¶Department of Biochemistry, Imperial College of Science, Medicine and Technology, London SW7 2AY, England
The functional state of the skeletal muscle
Ca2+ release channel is modulated by a number of endogenous
molecules during excitation-contraction. Using electron cryomicroscopy
and angular reconstitution techniques, we determined the
three-dimensional (3D) structure of the skeletal muscle
Ca2+ release channel activated by a nonhydrolyzable analog
of ATP in the presence of Ca2+. These ligands together
produce almost maximum activation of the channel and drive the channel
population toward a predominately open state. The resulting 30-Å 3D
reconstruction reveals long-range conformational changes in the
cytoplasmic region that might affect the interaction of the
Ca2+ release channel with the t-tubule voltage sensor. In
addition, a central opening and mass movements, detected in the
transmembrane domain of both the Ca2+- and the
Ca2+/nucleotide-activated channels, suggest a mechanism for
channel opening similar to opening-closing of the iris in a camera diaphragm.
Biophys J, October 1999, p. 1936-1944, Vol. 77, No. 4
© 1999 by the Biophysical Society 0006-3495/99/10/1936/09 $2.00
This article has been cited by other articles:
 |
|
 |
|
  I. I. Serysheva, S. J. Ludtke, M. L. Baker, Y. Cong, M. Topf, D. Eramian, A. Sali, S. L. Hamilton, and W. Chiu Subnanometer-resolution electron cryomicroscopy-based domain models for the cytoplasmic region of skeletal muscle RyR channel PNAS, July 15, 2008; 105(28): 9610 - 9615. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Akita and K. Kuba Ca2+-dependent inactivation of Ca2+-induced Ca2+ release in bullfrog sympathetic neurons J. Physiol., July 15, 2008; 586(14): 3365 - 3384. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Koop, P. Goldmann, S. R. W. Chen, R. Thieleczek, and M. Varsanyi ARVC-Related Mutations in Divergent Region 3 Alter Functional Properties of the Cardiac Ryanodine Receptor Biophys. J., June 15, 2008; 94(12): 4668 - 4677. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. E. D. J. ter Keurs and P. A. Boyden Calcium and Arrhythmogenesis Physiol Rev, April 1, 2007; 87(2): 457 - 506. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Milting, N. Lukas, B. Klauke, R. Korfer, A. Perrot, K.-J. Osterziel, J. Vogt, S. Peters, R. Thieleczek, and M. Varsanyi Composite polymorphisms in the ryanodine receptor 2 gene associated with arrhythmogenic right ventricular cardiomyopathy Cardiovasc Res, August 1, 2006; 71(3): 496 - 505. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Sharma, L. H. Jeyakumar, S. Fleischer, and T. Wagenknecht Three-Dimensional Visualization of FKBP12.6 Binding to an Open Conformation of Cardiac Ryanodine Receptor Biophys. J., January 1, 2006; 90(1): 164 - 172. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Di Biase and C. Franzini-Armstrong Evolution of skeletal type e-c coupling: a novel means of controlling calcium delivery J. Cell Biol., November 21, 2005; 171(4): 695 - 704. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-F. Hu, X. Liang, K.-Y. Chen, H. Xie, Y. Xu, P.-H. Zhu, and J. Hu Modulation of the Oligomerization of Isolated Ryanodine Receptors by their Functional States Biophys. J., September 1, 2005; 89(3): 1692 - 1699. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. E. Lehnart, X. H.T. Wehrens, and A. R. Marks Defective Ryanodine Receptor Interdomain Interactions May Contribute to Intracellular Ca2+ Leak: A Novel Therapeutic Target in Heart Failure Circulation, June 28, 2005; 111(25): 3342 - 3346. [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Blayney, S. Zissimopoulos, E. Ralph, E. Abbot, L. Matthews, and F. A. Lai Ryanodine Receptor Oligomeric Interaction: IDENTIFICATION OF A PUTATIVE BINDING REGION J. Biol. Chem., April 9, 2004; 279(15): 14639 - 14648. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Protasi, A. Shtifman, F. J. Julian, and P. D. Allen All three ryanodine receptor isoforms generate rapid cooling responses in muscle cells Am J Physiol Cell Physiol, March 1, 2004; 286(3): C662 - C670. [Abstract] [Full Text]
|
|
|
|
|
|
C. W. Ward, W. Feng, J. Tu, I. N. Pessah, P. K. Worley, and M. F. Schneider Homer Protein Increases Activation of Ca2+ Sparks in Permeabilized Skeletal Muscle J. Biol. Chem., February 13, 2004; 279(7): 5781 - 5787. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Peng, N. G. Publicover, G. J. Kargacin, D. Duan, J. A. Airey, and J. L. Sutko Imaging Single Cardiac Ryanodine Receptor Ca2+ Fluxes in Lipid Bilayers Biophys. J., January 1, 2004; 86(1): 134 - 144. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. I. Anyatonwu, E. D. Buck, and B. E. Ehrlich Methanethiosulfonate Ethylammonium Block of Amine Currents through the Ryanodine Receptor Reveals Single Pore Architecture J. Biol. Chem., November 14, 2003; 278(46): 45528 - 45538. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Chen, E. Esteve, J.-M. Sabatier, M. Ronjat, M. De Waard, P. D. Allen, and I. N. Pessah Maurocalcine and Peptide A Stabilize Distinct Subconductance States of Ryanodine Receptor Type 1, Revealing a Proportional Gating Mechanism J. Biol. Chem., April 25, 2003; 278(18): 16095 - 16106. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zhang, Z. Liu, H. Masumiya, R. Wang, D. Jiang, F. Li, T. Wagenknecht, and S. R. W. Chen Three-dimensional Localization of Divergent Region 3 of the Ryanodine Receptor to the Clamp-shaped Structures Adjacent to the FKBP Binding Sites J. Biol. Chem., April 11, 2003; 278(16): 14211 - 14218. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Baker, I. I. Serysheva, S. Sencer, Y. Wu, S. J. Ludtke, W. Jiang, S. L. Hamilton, and W. Chiu The skeletal muscle Ca2+ release channel has an oxidoreductase-like domain PNAS, September 17, 2002; 99(19): 12155 - 12160. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. I. Serysheva, S. J. Ludtke, M. R. Baker, W. Chiu, and S. L. Hamilton Structure of the voltage-gated L-type Ca2+ channel by electron cryomicroscopy PNAS, August 6, 2002; 99(16): 10370 - 10375. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. K. Shah and R. Sowdhamini Structural understanding of the transmembrane domains of inositol triphosphate receptors and ryanodine receptors towards calcium channeling Protein Eng. Des. Sel., November 1, 2001; 14(11): 867 - 874. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Sharma, L. H. Jeyakumar, S. Fleischer, and T. Wagenknecht Three-dimensional Structure of Ryanodine Receptor Isoform Three in Two Conformational States as Visualized by Cryo-electron Microscopy J. Biol. Chem., March 24, 2000; 275(13): 9485 - 9491. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Liu, J. Zhang, M. R. Sharma, P. Li, S. R. W. Chen, and T. Wagenknecht Three-dimensional reconstruction of the recombinant type 3 ryanodine receptor and localization of its amino terminus PNAS, May 22, 2001; 98(11): 6104 - 6109. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
