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Biophys J, January 2000, p. 334-343, Vol. 78, No. 1

Potentiation of Fractional Sarcoplasmic Reticulum Calcium Release by Total and Free Intra-Sarcoplasmic Reticulum Calcium Concentration

Thomas R. Shannon, Kenneth S. Ginsburg, and Donald M. Bers

Department of Physiology, Loyola University Chicago, Maywood, Illinois 60153 USA

Our aim was to measure the influence of sarcoplasmic reticulum (SR) calcium content ([Ca]SRT) and free SR [Ca] ([Ca]SR) on the fraction of SR calcium released during voltage clamp steps in isolated rabbit ventricular myocytes. [Ca]SRT, as measured by caffeine application, was progressively increased by conditioning pulses. Sodium was absent in both the intracellular and in the extracellular solutions to block sodium/calcium exchange. Total cytosolic calcium flux during the transient was inferred from ICa, [Ca]SRT, [Ca]i, and cellular buffering characteristics. Fluxes via the calcium current (ICa), the SR calcium pump, and passive leak from the SR were evaluated to determine SR calcium release flux (Jrel). Excitation-contraction (EC) coupling was characterized with respect to both gain (int Jrel/int ICa) and fractional SR calcium release. Both parameters were virtually zero for a small, but measurable [Ca]SRT. Gain and fractional SR calcium release increased steeply and nonlinearly with both [Ca]SRT and [Ca]SR. We conclude that potentiation of EC coupling can be correlated with both [Ca]SRT and [Ca]SR. While fractional SR calcium release was not linearly dependent upon [Ca]SR, intra-SR calcium may play a crucial role in regulating the SR calcium release process.

Biophys J, January 2000, p. 334-343, Vol. 78, No. 1
© 2000 by the Biophysical Society   0006-3495/00/01/334/10  $2.00


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