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Biophys J, May 2000, p. 2257-2269, Vol. 78, No. 5

Lateral Diffusion of Membrane Proteins in the Presence of Static and Dynamic Corrals: Suggestions for Appropriate Observables

Frank L. H. Brown, David M. Leitner, J. Andrew McCammon, and Kent R. Wilson

Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093-0339 USA

We consider the possibility of inferring the nature of cytoskeletal interaction with transmembrane proteins via optical experiments such as single-particle tracking (SPT) and near-field scanning optical microscopy (NSOM). In particular, we demonstrate that it may be possible to differentiate between static and dynamic barriers to diffusion by examining the time-dependent variance and higher moments of protein population inside cytoskeletal "corrals." Simulations modeling Band 3 diffusion on the surface of erythrocytes provide a concrete demonstration that these statistical tools might prove useful in the study of biological systems.

Biophys J, May 2000, p. 2257-2269, Vol. 78, No. 5
© 2000 by the Biophysical Society   0006-3495/00/05/2257/13  $2.00


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