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Biophys J, June 2000, p. 2735-2751, Vol. 78, No. 6
Molecular and Cell Biology Department, Neurobiology Division, University of California, Berkeley, California 94720 USA
Facilitation is an important form of short-term
plasticity that occurs in most synapses. At crayfish neuromuscular
junctions, basal transmission and facilitation were significantly
reduced after presynaptic introduction of "fast" high-affinity
calcium buffers, and the decay of facilitation was accelerated. The
existence of residual calcium during facilitation was also
demonstrated. Computational modeling of three-dimensional buffered
Ca2+ diffusion and binding to secretory and facilitation
targets suggest that the facilitation site is located away from a
secretory trigger mediating exocytosis; otherwise, the facilitation
site would be saturated by each action potential. Our simulations
account for many characteristics of facilitation and effects of
exogenous buffer, and suggest that facilitation is caused by residual
calcium gaining access to a site distinct from the secretory trigger
through restricted diffusion.
Biophys J, June 2000, p. 2735-2751, Vol. 78, No. 6
© 2000 by the Biophysical Society 0006-3495/00/06/2735/17 $2.00
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