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Biophys J, June 2000, p. 2761-2775, Vol. 78, No. 6
Cardiovascular Research Laboratory, Departments of Medicine (Cardiology), Physiology, and Physiological Science, University of California, Los Angeles, California 90095 USA
Scroll wave (vortex) breakup is hypothesized to underlie
ventricular fibrillation, the leading cause of sudden cardiac death. We
simulated scroll wave behaviors in a three-dimensional cardiac tissue
model, using phase I of the Luo-Rudy (LR1) action potential model. The
effects of action potential duration (APD) restitution, tissue
thickness, filament twist, and fiber rotation were studied. We found
that APD restitution is the major determinant of scroll wave behavior
and that instabilities arising from APD restitution are the main
determinants of scroll wave breakup in this cardiac model. We did not
see a "thickness-induced instability" in the LR1 model, but a
minimum thickness is required for scroll breakup in the presence of
fiber rotation. The major effect of fiber rotation is to maintain twist
in a scroll wave, promoting filament bending and thus scroll breakup.
In addition, fiber rotation induces curvature in the scroll wave, which
weakens conduction and further facilitates wave break.
Biophys J, June 2000, p. 2761-2775, Vol. 78, No. 6
© 2000 by the Biophysical Society 0006-3495/00/06/2761/15 $2.00
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