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Biophys J, June 2000, p. 2798-2813, Vol. 78, No. 6

The Mechanochemistry of V-ATPase Proton Pumps

Michael Grabe,* Hongyun Wang,dagger and George Osterdagger

 *Departments of Physics and  dagger Molecular and Cellular Biology and College of Natural Resources, University of California, Berkeley, California 94720-3112 USA

The vacuolar H+-ATPases (V-ATPases) are a universal class of proton pumps that are structurally similar to the F-ATPases. Both protein families are characterized by a membrane-bound segment (Vo, Fo) responsible for the translocation of protons, and a soluble portion, (V1, F1), which supplies the energy for translocation by hydrolyzing ATP. Here we present a mechanochemical model for the functioning of the Vo ion pump that is consistent with the known structural features and biochemistry. The model reproduces a variety of experimental measurements of performance and provides a unified view of the many mechanisms of intracellular pH regulation.

Biophys J, June 2000, p. 2798-2813, Vol. 78, No. 6
© 2000 by the Biophysical Society   0006-3495/00/06/2798/16  $2.00


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