| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Biophys J, June 2000, p. 2844-2862, Vol. 78, No. 6
*Department of Biomedical Engineering, Center for Hearing Sciences
and Center for Computational Medicine and Biology, The Johns Hopkins
University School of Medicine, Baltimore, Maryland 21205 and
Bobby R. Alford Department of Otorhinolaryngology and
Communicative Sciences, Baylor College of Medicine, Houston, Texas
77030 USA
We propose a new mechanism for outer hair cell
electromotility based on electrically induced localized changes in the
curvature of the plasma membrane (flexoelectricity). Electromechanical
coupling in the cell's lateral wall is modeled in terms of linear
constitutive equations for a flexoelectric membrane and then extended
to nonlinear coupling based on the Langevin function. The Langevin
function, which describes the fraction of dipoles aligned with an
applied electric field, is shown to be capable of predicting the
electromotility voltage displacement function. We calculate the
electrical and mechanical contributions to the force balance and show
that the model is consistent with experimentally measured values for
electromechanical properties. The model rationalizes several
experimental observations associated with outer hair cell
electromotility and provides for constant surface area of the plasma
membrane. The model accounts for the isometric force generated by the
cell and explains the observation that the disruption of spectrin by
diamide reduces force generation in the cell. We discuss the relation
of this mechanism to other proposed models of outer hair cell
electromotility. Our analysis suggests that rotation of membrane
dipoles and the accompanying mechanical deformation may be the
molecular mechanism of electromotility.
Biophys J, June 2000, p. 2844-2862, Vol. 78, No. 6
© 2000 by the Biophysical Society 0006-3495/00/06/2844/19 $2.00
This article has been cited by other articles:
 |
|
 |
|
  V. Rybalchenko and J. Santos-Sacchi Anion Control of Voltage Sensing by the Motor Protein Prestin in Outer Hair Cells Biophys. J., November 1, 2008; 95(9): 4439 - 4447. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Ashmore Cochlear Outer Hair Cell Motility Physiol Rev, January 1, 2008; 88(1): 173 - 210. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Fang and K. H. Iwasa Effects of Chlorpromazine and Trinitrophenol on the Membrane Motor of Outer Hair Cells Biophys. J., September 1, 2007; 93(5): 1809 - 1817. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Dallos, J. Zheng, and M. A. Cheatham Prestin and the cochlear amplifier J. Physiol., October 1, 2006; 576(1): 37 - 42. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. G. Navarrete and J. Santos-Sacchi On the Effect of Prestin on the Electrical Breakdown of Cell Membranes Biophys. J., February 1, 2006; 90(3): 967 - 974. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Matsumoto and F. Kalinec Extraction of Prestin-Dependent and Prestin-Independent Components from Complex Motile Responses in Guinea Pig Outer Hair Cells Biophys. J., December 1, 2005; 89(6): 4343 - 4351. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Ermilov, D. R. Murdock, D. El-Daye, W. E. Brownell, and B. Anvari Effects of Salicylate on Plasma Membrane Mechanics J Neurophysiol, September 1, 2005; 94(3): 2105 - 2110. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhou and R. M. Raphael Effect of Salicylate on the Elasticity, Bending Stiffness, and Strength of SOPC Membranes Biophys. J., September 1, 2005; 89(3): 1789 - 1801. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Scherer and A. W. Gummer How Many States Can the Motor Molecule, Prestin, Assume in an Electric Field? Biophys. J., May 1, 2005; 88(5): L27 - L29. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Zelenskaya, J. Boutet de Monvel, D. Pesen, M. Radmacher, J. H. Hoh, and M. Ulfendahl Evidence for a Highly Elastic Shell-Core Organization of Cochlear Outer Hair Cells by Local Membrane Indentation Biophys. J., April 1, 2005; 88(4): 2982 - 2993. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-X. Dong and K. H. Iwasa Tension Sensitivity of Prestin: Comparison with the Membrane Motor in Outer Hair Cells Biophys. J., February 1, 2004; 86(2): 1201 - 1208. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Fridberger, J. Boutet de Monvel, and M. Ulfendahl Internal Shearing within the Hearing Organ Evoked by Basilar Membrane Motion J. Neurosci., November 15, 2002; 22(22): 9850 - 9857. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. F. Ashmore, G. S. G. Geleoc, and L. Harbott Molecular mechanisms of sound amplification in the mammalian cochlea PNAS, October 24, 2000; 97(22): 11759 - 11764. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Morimoto, R. M. Raphael, A. Nygren, and W. E. Brownell Excess plasma membrane and effects of ionic amphipaths on mechanics of outer hair cell lateral wall Am J Physiol Cell Physiol, May 1, 2002; 282(5): C1076 - C1086. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
