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Biophys J, June 2000, p. 3120-3137, Vol. 78, No. 6
Departments of *Veterinary and Comparative Anatomy, Physiology, and
Pharmacology and Biological Systems Engineering,
Washington State University, Pullman, WA 99164;
Department of Physics, Division of Biophysics, Moscow
State University, Moscow, Russia; and §Institute of
Theoretical and Experimental Biophysics, Russian Academy of Sciences,
Puschino, Russia
Cooperativity in contractile behavior of myofilament
systems almost assuredly arises because of interactions between
neighboring sites. These interactions may be of different kinds.
Tropomyosin thin-filament regulatory units may have neighbors in steric
blocking positions (off) or steric permissive positions
(on). The position of these neighbors influence the tendency
for the regulatory unit to assume the on or off state. Likewise, the
tendency of a myosin cross-bridge to achieve a force-bearing state may
be influenced by whether neighboring cross-bridges are in force-bearing
states. Also, a cross-bridge in the force-bearing state may influence the tendency of a regulatory unit to enter the on state. We
used a mathematical model to examine the influence of each of these three kinds of neighbor interactions on the steady-state force-pCa relation and on the dynamic force redevelopment process. Each neighbor
interaction was unique in its effects on maximal
Ca2+-activated force, position, and symmetry of the
force-pCa curve and on the Hill coefficient. Also, each neighbor
interaction had a distinctive effect on the time course of force
development as assessed by its rate coefficient,
kdev. These diverse effects suggest that
variations in all three kinds of nearest-neighbor interactions may be
responsible for a wide variety of currently unexplained observations of
myofilament contractile behavior.
Biophys J, June 2000, p. 3120-3137, Vol. 78, No. 6
© 2000 by the Biophysical Society 0006-3495/00/06/3120/18 $2.00
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