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Biophys J, September 2000, p. 1188-1195, Vol. 79, No. 3

Switching from Simple to Complex Oscillations in Calcium Signaling

U. Kummer,* L. F. Olsen,dagger C. J. Dixon,Dagger A. K. Green,Dagger E. Bornberg-Bauer,* and G. Baier§

 *European Media Laboratory, 69118 Heidelberg, Germany;  dagger Physical Biochemistry Group, Odense University, 5230 Odense, Denmark;  Dagger Department of Human Anatomy and Cell Biology, New Medical School, University of Liverpool, Liverpool L69 3GE, United Kingdom; and  §Universidad Autonoma del Estado de Morelos, Facultad de Ciencias, 62210 Cuernavaca, Morelos, Mexico

We present a new model for calcium oscillations based on experiments in hepatocytes. The model considers feedback inhibition on the initial agonist receptor complex by calcium and activated phospholipase C, as well as receptor type-dependent self-enhanced behavior of the activated Galpha subunit. It is able to show simple periodic oscillations and periodic bursting, and it is the first model to display chaotic bursting in response to agonist stimulations. Moreover, our model offers a possible explanation for the differences in dynamic behavior observed in response to different agonists in hepatocytes.

Biophys J, September 2000, p. 1188-1195, Vol. 79, No. 3
© 2000 by the Biophysical Society   0006-3495/00/09/1188/08  $2.00


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