help button home button Biophys. J.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Strunz, T.
Right arrow Articles by Hegner, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Strunz, T.
Right arrow Articles by Hegner, M.

Biophys J, September 2000, p. 1206-1212, Vol. 79, No. 3

Model Energy Landscapes and the Force-Induced Dissociation of Ligand-Receptor Bonds

T. Strunz, K. Oroszlan, I. Schumakovitch, H.-J. Güntherodt, and M. Hegner

Department of Physics and Astronomy, University of Basel, 4056 Basel, Switzerland

We discuss models for the force-induced dissociation of a ligand-receptor bond, occurring in the context of cell adhesion or single molecule unbinding force measurements. We consider a bond with a structured energy landscape which is modeled by a network of force dependent transition rates between intermediate states. The behavior of a model with only one intermediate state and a model describing a molecular zipper is studied. We calculate the bond lifetime as a function of an applied force and unbinding forces under an increasing applied load and determine the relationship between both quantities. The dissociation via an intermediate state can lead to distinct functional relations of the bond lifetime on force. One possibility is the occurrence of three force regimes where the lifetime of the bond is determined by different transitions within the energy landscape. This case can be related to recent experimental observations of the force-induced dissociation of single avidin-biotin bonds.

Biophys J, September 2000, p. 1206-1212, Vol. 79, No. 3
© 2000 by the Biophysical Society   0006-3495/00/09/1206/07  $2.00


This article has been cited by other articles:


Home page
 Biophys. JHome page
S. Guo, C. Ray, A. Kirkpatrick, N. Lad, and B. B. Akhremitchev
Effects of Multiple-Bond Ruptures on Kinetic Parameters Extracted from Force Spectroscopy Measurements: Revisiting Biotin-Streptavidin Interactions
Biophys. J., October 15, 2008; 95(8): 3964 - 3976.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
J. Nummela and I. Andricioaei
Exact Low-Force Kinetics from High-Force Single-Molecule Unfolding Events
Biophys. J., November 15, 2007; 93(10): 3373 - 3381.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
M. Andersson, B. E. Uhlin, and E. Fallman
The Biomechanical Properties of E. coli Pili for Urinary Tract Attachment Reflect the Host Environment
Biophys. J., November 1, 2007; 93(9): 3008 - 3014.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
M. Odorico, J.-M. Teulon, T. Bessou, C. Vidaud, L. Bellanger, S.-w. W. Chen, E. Quemeneur, P. Parot, and J.-L. Pellequer
Energy Landscape of Chelated Uranyl: Antibody Interactions by Dynamic Force Spectroscopy
Biophys. J., July 15, 2007; 93(2): 645 - 654.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
M. Raible, M. Evstigneev, F. W. Bartels, R. Eckel, M. Nguyen-Duong, R. Merkel, R. Ros, D. Anselmetti, and P. Reimann
Theoretical Analysis of Single-Molecule Force Spectroscopy Experiments: Heterogeneity of Chemical Bonds
Biophys. J., June 1, 2006; 90(11): 3851 - 3864.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
B. Bonanni, A. S. M. Kamruzzahan, A. R. Bizzarri, C. Rankl, H. J. Gruber, P. Hinterdorfer, and S. Cannistraro
Single Molecule Recognition between Cytochrome C 551 and Gold-Immobilized Azurin by Force Spectroscopy
Biophys. J., October 1, 2005; 89(4): 2783 - 2791.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
S. A. Harris, Z. A. Sands, and C. A. Laughton
Molecular Dynamics Simulations of Duplex Stretching Reveal the Importance of Entropy in Determining the Biomechanical Properties of DNA
Biophys. J., March 1, 2005; 88(3): 1684 - 1691.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
B. T. Marshall, K. K. Sarangapani, J. Lou, R. P. McEver, and C. Zhu
Force History Dependence of Receptor-Ligand Dissociation
Biophys. J., February 1, 2005; 88(2): 1458 - 1466.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
S. Pierrat, F. Brochard-Wyart, and P. Nassoy
Enforced Detachment of Red Blood Cells Adhering to Surfaces: Statics and Dynamics
Biophys. J., October 1, 2004; 87(4): 2855 - 2869.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
I. Derenyi, D. Bartolo, and A. Ajdari
Effects of Intermediate Bound States in Dynamic Force Spectroscopy
Biophys. J., March 1, 2004; 86(3): 1263 - 1269.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
L. A. Chtcheglova, G. T. Shubeita, S. K. Sekatskii, and G. Dietler
Force Spectroscopy with a Small Dithering of AFM Tip: A Method of Direct and Continuous Measurement of the Spring Constant of Single Molecules and Molecular Complexes
Biophys. J., February 1, 2004; 86(2): 1177 - 1184.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
K. Kawaguchi, S. Uemura, and S.'i. Ishiwata
Equilibrium and Transition between Single- and Double-Headed Binding of Kinesin as Revealed by Single-Molecule Mechanics
Biophys. J., February 1, 2003; 84(2): 1103 - 1113.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
C. Gergely, J. Hemmerle, P. Schaaf, J. K. H. Horber, J.-C. Voegel, and B. Senger
Multi-Bead-and-Spring Model to Interpret Protein Detachment Studied by AFM Force Spectroscopy
Biophys. J., August 1, 2002; 83(2): 706 - 722.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2000 by the Biophysical Society.