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Biophys J, September 2000, p. 1237-1252, Vol. 79, No. 3

Self-Regulation Phenomena in Bacterial Reaction Centers. I. General Theory

Alexander O. Goushcha,*dagger Valery N. Kharkyanen,Dagger Gary W. Scott,dagger and Alfred R. Holzwarth*

 *Max-Planck-Institut für Strahlenchemie, Ruhr 45470, Germany;  dagger Department of Chemistry, University of California at Riverside, Riverside, California 92521 USA; and  Dagger Institute for Physics, National Academy of Science-Ukraine, Kyiv 252028, Ukraine

A model for light-induced charge separation in a donor-acceptor system of the reaction center of photosynthetic bacteria is described. This description is predicated on a self-regulation of the flow of photo-activated electrons due to self-consistent, slow structural rearrangements of the macromolecule. Effects of the interaction between the separated charges and the slow structural modes of the biomolecule may accumulate during multiple, sequential charge transfer events. This accumulation produces non-linear dynamic effects on system function, providing a regulation of the charge separation efficiency. For a biomolecule with a finite number of different charge-transfer states, the quasi-stationary populations of these states with a localized electron on different cofactors may deviate from a Lagmuir law dependence with actinic light intensity. Such deviations are predicted by the model to be due to light-induced structural changes. The theory of self-regulation developed here assumes that light-induced changes in the effective adiabatic potential occur along a slow structural coordinate. In this model, a "light-adapted" conformational state appears when bifurcation produces a new minimum in the adiabatic potential. In this state, the lifetime of the charge-separated state may be quite different from that of the "dark-adapted" conformation. The results predicted by this theory agree with previously obtained experimental results on photosynthetic reaction centers.

Biophys J, September 2000, p. 1237-1252, Vol. 79, No. 3
© 2000 by the Biophysical Society   0006-3495/00/09/1237/16  $2.00


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