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Biophys J, November 2000, p. 2259-2275, Vol. 79, No. 5
and
*UMR 168 "Physico-chimie," CNRS/Institut Curie, Section de
Recherche, 75248 Paris, France; Department of Physics,
Princeton University, Princeton, New Jersey 08544 USA; and
Department of Physics, Bar-Ilan University, Ramat-Gan
52900, Israel
The bacterium Listeria monocytogenes uses the
energy of the actin polymerization to propel itself through infected
tissues. In steady state, it continuously adds new polymerized
filaments to its surface, pushing on its tail, which is made from
previously cross-linked actin filaments. In this paper we introduce an
elastic model to describe how the addition of actin filaments to the
tail results in the propulsive force on the bacterium. Filament growth on the bacterial surface produces stresses that are relieved at the
back of the bacterium as it moves forward. The model leads to a natural
competition between growth from the sides and growth from the back of
the bacterium, with different velocities and strengths for each. This
competition can lead to the periodic motion observed in a
Listeria mutant.
Biophys J, November 2000, p. 2259-2275, Vol. 79, No. 5
© 2000 by the Biophysical Society 0006-3495/00/11/2259/17 $2.00
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