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Biophys J, December 2000, p. 2801-2817, Vol. 79, No. 6
and
*Department of Physiology and Biophysics, University of Washington,
Seattle, Washington 98195 and Bell Laboratories, Lucent
Technologies, Murray Hill, New Jersey 07974 USA
Identifying the basic module of enzymatic amplification
as an irreversible cycle of messenger activation/deactivation by a "push-pull" pair of opposing enzymes, we analyze it in terms of gain, bandwidth, noise, and power consumption. The enzymatic signal transduction cascade is viewed as an information channel, the design of
which is governed by the statistical properties of the input and the
noise and dynamic range constraints of the output. With the example of
vertebrate phototransduction cascade we demonstrate that all of the
relevant engineering parameters are controlled by enzyme concentrations
and, from functional considerations, derive bounds on the required
protein numbers. Conversely, the ability of enzymatic networks to
change their response characteristics by varying only the abundance of
different enzymes illustrates how functional diversity may be built
from nearly conserved molecular components.
Biophys J, December 2000, p. 2801-2817, Vol. 79, No. 6
© 2000 by the Biophysical Society 0006-3495/00/12/2801/17 $2.00
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