| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Biophys J, December 2000, p. 2840-2857, Vol. 79, No. 6
and
* Department of Pure and Applied Mathematics, Washington
State University, Pullman, Washington 99164-3113 USA;
Theoretical Biology and Biophysics Group, Los
Alamos National Laboratory, Los Alamos, New Mexico 87545 USA; and
Groupe de Recherche en Transport
Membranaire, Départements de Physique et de Chimie,
Université de Montréal, Québec H3C 3J7, Canada
We develop a model for proton conduction through
gramicidin based on the molecular dynamics simulations of Pomès
and Roux (Biophys. J. 72:A246, 1997). The transport
of a single proton through the gramicidin pore is described by a
potential of mean force and diffusion coefficient obtained from the
molecular dynamics. In addition, the model incorporates the dynamics of
a defect in the hydrogen bonding structure of pore waters without an
excess proton. Proton entrance and exit were not simulated by the
molecular dynamics. The single proton conduction model includes a
simple representation of these processes that involves three free
parameters. A reasonable value can be chosen for one of these, and the
other two can be optimized to yield a good fit to the proton
conductance data of Eisenman et al. (1980, Ann. N.Y. Acad.
Sci. 339:8-20) for pH 
1.7. A sensitivity analysis shows
the significance of this fit.
Biophys J, December 2000, p. 2840-2857, Vol. 79, No. 6
© 2000 by the Biophysical Society 0006-3495/00/12/2840/18 $2.00
This article has been cited by other articles:
 |
|
 |
|
  B. A. Feniouk, M. A. Kozlova, D. A. Knorre, D. A. Cherepanov, A. Y. Mulkidjanian, and W. Junge The Proton-Driven Rotor of ATP Synthase: Ohmic Conductance (10 fS), and Absence of Voltage Gating Biophys. J., June 1, 2004; 86(6): 4094 - 4109. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Lu, P. Grayson, and K. Schulten Glycerol Conductance and Physical Asymmetry of the Escherichia coli Glycerol Facilitator GlpF Biophys. J., November 1, 2003; 85(5): 2977 - 2987. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Berneche and B. Roux A microscopic view of ion conduction through the K+ channel PNAS, July 22, 2003; 100(15): 8644 - 8648. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Serowy, S. M. Saparov, Y. N. Antonenko, W. Kozlovsky, V. Hagen, and P. Pohl Structural Proton Diffusion along Lipid Bilayers Biophys. J., February 1, 2003; 84(2): 1031 - 1037. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Smondyrev and G. A. Voth Molecular Dynamics Simulation of Proton Transport through the Influenza A Virus M2 Channel Biophys. J., October 1, 2002; 83(4): 1987 - 1996. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Gowen, J. C. Markham, S. E. Morrison, T. A. Cross, D. D. Busath, E. J. Mapes, and M. F. Schumaker The Role of Trp Side Chains in Tuning Single Proton Conduction through Gramicidin Channels Biophys. J., August 1, 2002; 83(2): 880 - 898. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
