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Biophysical Journal 8: 1236-1255 (1968)
© 1968 the Biophysical Society

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A Model of Alpha-Helical Distribution in Proteins

John W. Prothero

ABSTRACT

It is shown that alpha-helical content of eleven proteins is well correlated with alanine plus leucine content. These residues, taken singly or together, are to a first approximation randomly distributed in the four proteins whose tertiary structures have been determined (i.e., myoglobin, lysozyme, ribonuclease, {alpha}-chymotrypsin). A model based on the concept that certain randomly distributed residues specifically participate in helix nucleation is shown to be in reasonable agreement with the presently published structures.






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Copyright © 1968 by the Biophysical Society.