help button home button Biophys. J.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schumaker, M. F.
Right arrow Articles by Roux, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schumaker, M. F.
Right arrow Articles by Roux, B.

Biophys J, January 2001, p. 12-30, Vol. 80, No. 1

Framework Model For Single Proton Conduction through Gramicidin

Mark F. Schumaker,* Régis Pomès,dagger and Benoît RouxDagger

 * Department of Pure and Applied Mathematics, Washington State University, Pullman, Washington 99164-3113, USA,  dagger Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, and  Dagger Groupe de Recherche en Transport Membranaire, Départements de Physique et de Chimie, Université de Montréal, Québec H3C 3J7, Canada

This paper describes a framework model for proton conduction through gramicidin; a model designed to incorporate information from molecular dynamics and use this to predict conductance properties. The state diagram describes both motion of an excess proton within the pore as well as the reorientation of waters within the pore in the absence of an excess proton. The model is constructed as the diffusion limit of a random walk, allowing control over the boundary behavior of trajectories. Simple assumptions about the boundary behavior are made, which allow an analytical solution for the proton current and conductance. This is compared with corresponding expressions from statistical mechanics. The random walk construction allows diffusing trajectories underlying the model to be simulated in a simple way. Details of the numerical algorithm are described.

Biophys J, January 2001, p. 12-30, Vol. 80, No. 1
© 2001 by the Biophysical Society   0006-3495/01/01/12/19  $2.00


This article has been cited by other articles:


Home page
 Biophys. JHome page
T. Chou
Water Alignment, Dipolar Interactions, and Multiple Proton Occupancy during Water-Wire Proton Transport
Biophys. J., May 1, 2004; 86(5): 2827 - 2836.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. W. Allen, O. S. Andersen, and B. Roux
Energetics of ion conduction through the gramicidin channel
PNAS, January 6, 2004; 101(1): 117 - 122.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
D. Lu, P. Grayson, and K. Schulten
Glycerol Conductance and Physical Asymmetry of the Escherichia coli Glycerol Facilitator GlpF
Biophys. J., November 1, 2003; 85(5): 2977 - 2987.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Berneche and B. Roux
A microscopic view of ion conduction through the K+ channel
PNAS, July 22, 2003; 100(15): 8644 - 8648.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
S. Serowy, S. M. Saparov, Y. N. Antonenko, W. Kozlovsky, V. Hagen, and P. Pohl
Structural Proton Diffusion along Lipid Bilayers
Biophys. J., February 1, 2003; 84(2): 1031 - 1037.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
C. D. Cole, A. S. Frost, N. Thompson, M. Cotten, T. A. Cross, and D. D. Busath
Noncontact Dipole Effects on Channel Permeation. VI. 5F- and 6F-Trp Gramicidin Channel Currents
Biophys. J., October 1, 2002; 83(4): 1974 - 1986.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
A. M. Smondyrev and G. A. Voth
Molecular Dynamics Simulation of Proton Transport through the Influenza A Virus M2 Channel
Biophys. J., October 1, 2002; 83(4): 1987 - 1996.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
J. A. Gowen, J. C. Markham, S. E. Morrison, T. A. Cross, D. D. Busath, E. J. Mapes, and M. F. Schumaker
The Role of Trp Side Chains in Tuning Single Proton Conduction through Gramicidin Channels
Biophys. J., August 1, 2002; 83(2): 880 - 898.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2001 by the Biophysical Society.