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Biophys J, April 2001, p. 1712-1721, Vol. 80, No. 4

Predicted Profiles of Ion Concentrations in Olfactory Cilia in the Steady State

Bernd Lindemann

Department of Physiology, Universität des Saarlandes, D-66421 Homburg, Germany

The role of ciliary geometry for transduction events was explored by numerical simulation. The changes in intraciliary ion concentrations, suspected to occur during transduction, could thus be estimated. The case of a single excised cilium, having a uniform distribution of membrane channels, voltage clamped to -80 mV, was especially investigated. The axial profile of membrane voltage was that of a leaky cable. The Ca2+ concentration profile tended to show a maximum in proximal segments, due to a preponderance of Ca2+ inflow over Ca2+ export at those locations. The local increase in Ca2+ concentration activated Cl- channels. The resulting current caused a local drop in Cl- concentration, especially at the tip of the cilium and in distal segments, accompanied by a drop in ciliary K+ concentration. In consequence, the membrane Cl- current was low in distal segments but stronger in proximal segments, where resupply was sufficient. The model predicts that the Cl- depletion will codetermine the time course of the receptor potential or current and the ciliary stimulus-response curve. In conclusion, when modeling with transduction elements presently known to participate, the ciliary geometry has large effects on ion distributions and transduction currents because ciliary ion transport is limited by axial electrodiffusion.

Biophys J, April 2001, p. 1712-1721, Vol. 80, No. 4
© 2001 by the Biophysical Society   0006-3495/01/04/1712/10  $2.00


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