help button home button Biophys. J.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chow, D. C.
Right arrow Articles by Papoutsakis, E. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chow, D. C.
Right arrow Articles by Papoutsakis, E. T.

Biophys J, August 2001, p. 675-684, Vol. 81, No. 2

Modeling pO2 Distributions in the Bone Marrow Hematopoietic Compartment. I. Krogh's Model

Dominic C. Chow, Larissa A. Wenning, William M. Miller, and E. Terry Papoutsakis

Department of Chemical Engineering, Northwestern University, Evanston, Illinois 60208-3120 USA

Human bone marrow (BM) is a tissue of complex architectural organization, which includes granulopoietic loci, erythroblastic islets, and lymphocytic nodules. Oxygen tension (pO2) is an important determinant of hematopoietic stem and progenitor cell proliferation and differentiation. Thus, understanding the impact of the BM architectural organization on pO2 levels in extravascular hematopoietic tissue is an important biophysical problem. However, currently it is impossible to measure pO2 levels and their spatial variations in the BM. Homogeneous Kroghian models were used to estimate pO2 distribution in the BM hematopoietic compartment (BMHC) and to conservatively simulate pO2-limited cellular architectures. Based on biophysical data of hematopoietic cells and characteristics of BM physiology, we constructed a tissue cylinder solely occupied by granulocytic progenitors (the most metabolically active stage of the most abundant cell type) to provide a physiologically relevant limiting case. Although the number of possible cellular architectures is large, all simulated pO2 profiles fall between two extreme cases: those of homogeneous tissues with adipocytes and granulocytic progenitors, respectively. This was illustrated by results obtained from a parametric criterion derived for pO2 depletion in the extravascular tissue. Modeling results suggest that stem and progenitor cells experience a low pO2 environment in the BMHC.

Biophys J, August 2001, p. 675-684, Vol. 81, No. 2
© 2001 by the Biophysical Society   0006-3495/01/08/675/10  $2.00


This article has been cited by other articles:


Home page
 Circ. Res.Home page
F. Loffredo and R. T. Lee
Therapeutic Vasculogenesis: It Takes Two
Circ. Res., July 18, 2008; 103(2): 128 - 130.
[Full Text] [PDF]

Home page
 BloodHome page
O. Krejci, M. Wunderlich, H. Geiger, F.-S. Chou, D. Schleimer, M. Jansen, P. R. Andreassen, and J. C. Mulloy
p53 signaling in response to increased DNA damage sensitizes AML1-ETO cells to stress-induced death
Blood, February 15, 2008; 111(4): 2190 - 2199.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J. L. Chan, K. C. Tang, A. P. Patel, L. M. Bonilla, N. Pierobon, N. M. Ponzio, and P. Rameshwar
Antigen-presenting property of mesenchymal stem cells occurs during a narrow window at low levels of interferon-{gamma}
Blood, June 15, 2006; 107(12): 4817 - 4824.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Piccoli, R. Ria, R. Scrima, O. Cela, A. D'Aprile, D. Boffoli, F. Falzetti, A. Tabilio, and N. Capitanio
Characterization of Mitochondrial and Extra-mitochondrial Oxygen Consuming Reactions in Human Hematopoietic Stem Cells: NOVEL EVIDENCE OF THE OCCURRENCE OF NAD(P)H OXIDASE ACTIVITY
J. Biol. Chem., July 15, 2005; 280(28): 26467 - 26476.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K. R. Atkuri, L. A. Herzenberg, and L. A. Herzenberg
Culturing at atmospheric oxygen levels impacts lymphocyte function
PNAS, March 8, 2005; 102(10): 3756 - 3759.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
T. Fink, L. Abildtrup, K. Fogd, B. M. Abdallah, M. Kassem, P. Ebbesen, and V. Zachar
Induction of Adipocyte-Like Phenotype in Human Mesenchymal Stem Cells by Hypoxia
Stem Cells, December 1, 2004; 22(7): 1346 - 1355.
[Abstract] [Full Text] [PDF]

Home page
 JBJSHome page
G. F. Muschler, C. Nakamoto, and L. G. Griffith
Engineering Principles of Clinical Cell-Based Tissue Engineering
J. Bone Joint Surg. Am., July 1, 2004; 86(7): 1541 - 1558.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. A. Potian, H. Aviv, N. M. Ponzio, J. S. Harrison, and P. Rameshwar
Veto-Like Activity of Mesenchymal Stem Cells: Functional Discrimination Between Cellular Responses to Alloantigens and Recall Antigens
J. Immunol., October 1, 2003; 171(7): 3426 - 3434.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
D. L. Hevehan, W. M. Miller, and E. T. Papoutsakis
Differential expression and phosphorylation of distinct STAT3 proteins during granulocytic differentiation
Blood, March 1, 2002; 99(5): 1627 - 1637.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2001 by the Biophysical Society.