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Biophys J, November 2001, p. 2425-2441, Vol. 81, No. 5

Geometrical Properties of Gel and Fluid Clusters in DMPC/DSPC Bilayers: Monte Carlo Simulation Approach Using a Two-State Model

István P. Sugár,* Ekaterina Michonova-Alexova,* and Parkson Lee-Gau Chongdagger

 *Departments of Biomathematical Sciences and Physiology/Biophysics, The Mount Sinai Medical Center, New York, New York 10029; and  dagger Department of Biochemistry, Temple University, Philadelphia, Pennsylvania 19140 USA

In this paper the geometrical properties of gel and fluid clusters of equimolar dimyristoylphosphatidylcholine/distearoylphosphatidylcholine (DMPC/DSPC) lipid bilayers are calculated by using an Ising-type model (Sugar, I. P., T. E. Thompson, and R. L. Biltonen. 1999. Biophys. J. 76:2099-2110). The model is able to predict the following properties in agreement with the respective experimental data: the excess heat capacity curves, fluorescence recovery after photobleaching (FRAP) threshold temperatures at different mixing ratios, the most frequent center-to-center distance between DSPC clusters, and the fractal dimension of gel clusters. In agreement with the neutron diffraction and fluorescence microscopy data, the simulations show that below the percolation threshold temperature of gel clusters many nanometer-size gel clusters co-exist with one large gel cluster of size comparable with the membrane surface area. With increasing temperature the calculated effective fractal dimension and capacity dimension of gel and fluid clusters decrease and increase, respectively, within the (0, 2) interval. In the region of the gel-to-fluid transition the following geometrical properties are independent from the temperature and the state of the cluster: 1) the cluster perimeter linearly increases with the number of cluster arms at a rate of 8.2 nm/arm; 2) the average number of inner islands in a cluster increases with increasing cluster size, S, according to a power function of 0.00427 × S1.3; 3) the following exponential function describes the average size of an inner island versus the size of the host cluster, S: 1 + 1.09(1 - e-0.0072×S). By means of the equations describing the average geometry of the clusters the process of the association of clusters is investigated.

Biophys J, November 2001, p. 2425-2441, Vol. 81, No. 5
© 2001 by the Biophysical Society   0006-3495/01/11/2425/17  $2.00


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