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Biophys J, November 2001, p. 2693-2706, Vol. 81, No. 5
and
Department of Biochemistry, University of Alberta,
Edmonton, Alberta T6G 2H7, Canada and Department of
Physics, Princeton University, Princeton, New Jersey 05844, USA
X-ray diffraction is used to solve the low-resolution
structures of fully hydrated aqueous dispersions of seven different diacyl phosphatidylethanolamines (PEs) whose hydrocarbon chains have
the same effective chain length but whose structures vary widely. Both
the lower-temperature, liquid-crystalline lamellar (L
)
and the higher-temperature, inverted hexagonal (HII) phase
structures are solved, and the resultant internal dimensions (d-spacing, water layer thickness, average lipid length, and headgroup area at the lipid-water interface) of each phase are determined as a
function of temperature. The magnitude of the L and HII phase d-spacings on either side of the
L/HII phase transition temperature
(Th) depends significantly on the structure of
the PE hydrocarbon chains. The L phase d-spacings range
from 51.2 to 56.4 Å, whereas those of the HII phase range
from 74.9 to 82.7 Å. These new results differ from our earlier
measurements of these PEs (Lewis et al., Biochemistry,
28:541-548, 1989), which found near constant d-spacings of 52.5 and
77.0-78.0 Å for the L and HII phases,
respectively. In both phases, the d-spacings decrease with increasing
temperature independent of chain structure, but, in both phases, the
rate of decrease in the L phase is smaller than that in
the HII phase. A detailed molecular description of the
L/HII phase transition in these PEs is also presented.
Biophys J, November 2001, p. 2693-2706, Vol. 81, No. 5
© 2001 by the Biophysical Society 0006-3495/01/11/2693/14 $2.00
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