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Biophys J, December 2001, p. 3016-3028, Vol. 81, No. 6

Multi-Stage Regulation, a Key to Reliable Adaptive Biochemical Pathways

Gal Almogy,*dagger Lewi Stone,* and Nir Ben-Taldagger

 *Biomathematics Unit, Department of Zoology and  dagger Department of Biochemistry, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv 69978, Israel

A general "multi-stage" regulation model, based on linearly connected regulatory units, is formulated to demonstrate how biochemical pathways may achieve high levels of accuracy. The general mechanism, which is robust to changes in biochemical parameters, such as protein concentration and kinetic rate constants, is incorporated into a mathematical model of the bacterial chemotaxis network and provides a new framework for explaining regulation and adaptiveness in this extensively studied system. Although conventional theories suggest that methylation feedback pathways are responsible for chemotactic regulation, the model, which is deduced from known experimental data, indicates that protein interactions downstream of the bacterial receptor complex, such as CheAs and CheZ, may play a crucial and complementary role.

Biophys J, December 2001, p. 3016-3028, Vol. 81, No. 6
© 2001 by the Biophysical Society   0006-3495/01/12/3016/13  $2.00


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