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Biophys J, October 2002, p. 1877-1890, Vol. 83, No. 4

A Theoretical Model of Slow Wave Regulation Using Voltage-Dependent Synthesis of Inositol 1,4,5-Trisphosphate

Mohammad S. Imtiaz,* David W. Smith,dagger and Dirk F. van Helden*

 *The Neuroscience Group, The Faculty of Medicine & Health Sciences, and  dagger School of Engineering, The University of Newcastle, NSW 2308, Australia

A qualitative mathematical model is presented that examines membrane potential feedback on synthesis of inositol 1,4,5-trisphosphate (IP3), and its role in generation and modulation of slow waves. Previous experimental studies indicate that slow waves show voltage dependence, and this is likely to result through membrane potential modulation of IP3. It is proposed that the observed response of the tissue to current pulse, pulse train, and maintained current injection can be explained by changes in IP3, modulated through a voltage-IP3 feedback loop. Differences underlying the tissue responses to current injections of opposite polarities are shown to be due to the sequence of events following such currents. Results from this model are consistent with experimental findings and provide further understanding of these experimental observations. Specifically, we find that membrane potential can induce, abolish, and modulate slow wave frequency by altering the excitability of the tissue through the voltage-IP3 feedback loop.

Biophys J, October 2002, p. 1877-1890, Vol. 83, No. 4
© 2002 by the Biophysical Society   0006-3495/02/10/1877/14  $2.00


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